Methods adequately described? Appropriate? Patients studied adequately described and their condition defined?

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• If you believe that you cannot judge a given article impartially, please return the manuscript immediately to the editor with that explanation.
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• Scientific reliability
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• Adequacy of abstract, keywords.
• Appropriateness of approach or experimental design, adequacy of experimental techniques (including statistics where appropriate, need for statistical assessment).
• Results relevant to a problem posed? Credible? Well presented?
• Soundness of conclusions and interpretation. Interpretation and conclusions warranted by the data? Reasonable speculation? Is the message clear?
• Relevance of discussion
• References up to date and relevant? Any glaring omissions?
• The relevance of the figures and table, clarity of legends and titles.
• Suitability for the TP and overall recommendations. Appropriate for general readership or more appropriate for a specialist journal?
• If not acceptable can the paper be made so?
• Ethical aspects
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• Suggested revisions should be couched as such, and not expressed as conditions of acceptance. Please distinguish between revisions considered essential and those judged merely desirable.
• Even if we do not accept a paper we would like to pass on constructive comments that might help the author to improve it. For this reason please give detailed comments (with references, if appropriate) that will help both the editors to make a decision on the paper and the authors to improve it.
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• The editor gratefully receives a reviewer's recommendations, but since the editorial decisions are usually based on evaluations derived from several sources, a reviewer should not expect the editor to honor his or her every recommendation.